The combobox would have to be unbound from any ControlSource. It will contain no value when the form is first opened but retain the value that was selected until it was changed or the form is closed.
This may be useful for data entry where the user is adding new records but not very useful for displaying existing records as the unbound combobox would not display the existing value. You would also have to set the value to the field in the BeforeUpdate event.
Code:
Private Sub Form_BeforeUpdate
Me!FieldName = Me.ComboboxName
End sub