Typically you would not create an accde until the very end of development and testing.
The steps are conceptual design, development, split database, test, review, accept for "production",
--then -- make a backup of your FE and BE. Create an accde from your FE for distribution.
Your backup of the FE from which you create the accde is absolutely necessary.
Guard it as gold. You must work with the accdb version when you modify anything in your front end. After you have made modifications to the FE (accdb), BACK IT UP!, then make an accde from a copy.
Bottom line --you can not adjust/modify an accde -- you modify the accdb from which the accde was made. Also, if you are running a MsAccess db with more than 1 user, you split your database.
Good luck.
see
this for more split info