AFAIK, you need the Excel reference to do automation. If not, that will be enlightening to say the least.
One thing that could be done is to have a table of references and check those against the references in the project. If one is missing, you could either attempt to re-establish it (which would likely fail if versions have changed) or provide a message. What you do there would depend on circumstances, but allowing an email to be sent to you might be an option - or simply asking the user to report the message. You don't have to shut down the db because of a missing ref, but it might be better to know about it before you start some process that will fail.
The more we hear silence, the more we begin to think about our value in this universe.
Paraphrase of Professor Brian Cox.