Not sure what you're asking.
If you split the db then make the fe connect to the be, the connection information is part of the fe design (table connection strings). Everyone who gets a copy of the fe should then be connected to the same be automatically as long as they have the right network permissions. However, one thing you have to be concerned about is that if the connection path is based on a network drive letter (e.g. F:\) everyone must be be using that drive letter. If not, connect using a UNC path.
The more we hear silence, the more we begin to think about our value in this universe.
Paraphrase of Professor Brian Cox.