I've been using MS Access since 1996, but since I switched to Office 2010 I've noticed a change. The prompt you get after changing a form or a table asking "Do you want to save changes..." used to come up immediately. Now, the first time you change anything you have to wait while the hard disk chugs away until the necessary code has been loaded and you get to see the prompt.
I find this particularly annoying, especially since many of the changes I'm being warned about would NOT be saved even if I answered 'Yes'. It's not that I don't want to see these prompts, I just don't want to have to wait 10 seconds or so the first time the mechanism is triggered.